Intermittent Fasting: Are There Any Benefits?

The potential health benefits associated with intermittent fasting continue to be a topic of great interest to myself, my clients and the public at large.

In previous blog posts I’ve discussed my experience with intermittent fasting  and also explored the popularized notion of working out in a “fasted state”.

More recently I’ve even explored whether or not fasting can actually alter gene expression.

Intermittent fasting is a VERY popular subject area and so I set myself to the task  of scanning the literature for high quality human evidence on the metabolic benefits of fasting – if any existed.

What I quickly learned is that the benefits of fasting can be divided into theoretical and findings-based categories.

Let’s take a closer look at both.

Theoretical Benefits Of Fasting

Intermittent fasting, like anything else, comes stocked with a list of theoretical benefits that may be partially supported by some level of literature evidence in either animals or humans.

These include:

1) Altered Lipid Metabolism:  In theory, because your body prefers to “burn fat” for fuel in a fasted state, it has been suggested that intermittent fasting may be superior to standard calorie reduction in supporting reductions in body fat.

I’ve not found any high quality human studies which suggest this to be the case but when it comes to general weight loss using intermittent fasting there are some things to keep in mind:

A systematic review and meta-analysis of human intervention studies using intermittent fasting as a weight loss treatment found it no more effective than continuous energy restriction.

There is also little evidence that intermittent fasting is superior at modulating resting energy expenditure(REE). REE, in essence, is the amount of energy a body expends at rest and not including other activities that would also require energy.

Some have suggested that fasting “boosts” your metabolism and one potential way to assess that is by measuring changes in resting energy expenditure in people doing intermittent fasting vs more conventional caloric reduction strategies.

No high quality evidence so far to show a compellingly differential effect.

2) Metabolic Flexibility: Because your body flips to fat metabolism in a fasted state, alterations occur on the cellular level ( including to your mitochondria) which some scientists suggest can promote what is known as metabolic flexibility, ultimately improving the health of your metabolism and functioning of your body on a metabolic level. Some believe, for example, that lacking metabolic flexibility contributes to insulin resistance in the long-term. Much more human evidence on the effects of fasting on this phenomenon will be required before firm conclusions can be drawn in this area.

3) Cellular & Metabolic Revitalization: This one is interesting and quite hard to prove with the current state of evidence, but some scientist suggest that the stress induced by fasting actually helps your bodily systems in the long-term. You can think about this along the same lines of taking a cold shower or an ice bath. It may not be particularly pleasant in the moment, but there are benefits to be had after it’s over.

Obviously further exploration and evidence will be required in this area but, to say the very least, the first meal one enjoys post-fast is highly enjoyable and reward on a number of levels ( speaking from limited experience!).

Does Really High Quality Human Evidence On Intermittent Fasting  Exist?

A very salient quote from a 2015 paper:

[W]hether fasting actually causes improvements in metabolic health, cognitive performance, and cardiovascular outcomes over the long term; how much fasting is actually beneficial; and where the threshold of hormesis resides (i.e., a balance between long-term benefit from fasting compared with harm from insufficient caloric intake) remain open questions. Unfortunately, the vast majority of human studies of a fasting intervention were weight-loss studies using single-arm, nonrandomized approaches or multiple intervention arms with no control.

For fasting to be more than a weight-loss fad, greater scientific rigor is needed from interventional trials than is found in the literature. Whereas enthusiasm for fasting is increasing, clinical relevance remains low because of insufficient human data, including almost nonexistent controlled trials

Intermittent Fasting And Diabetes-related Indicators

Insulin Resistance

Despite similarities in body fat loss between intermittent fasting and continuous energy restriction, there is some evidence to suggest that those who engage in fasting experience greater reductions in insulin resistance, which is a very fascinating consideration.


A 2018 randomized trial published in JAMA following patients with T2DM over 1 year period showed that intermittent fasting is no more effective than continuous energy restriction at reducing A1C ( a marker of blood sugar control).

Benefits Independent Of Weight Loss

So many people think of intermittent fasting purely as a means to an end when it comes to weight loss, but a very exciting new study has shown that fasting may offer health benefits independent of changes in weight.

A 2018 study out of Cell Metabolism explored, for the first time through a controlled trial, if fasting had metabolic benefits independent of weight loss.

They used a specific time of fasting ( early time-restricted feeding – eating early in day to align with circadian rhythm – finished eating by 3pm) and found it improved insulin sensitivity and blood pressure and reduced oxidative stress.

I actually discuss this particular topic, known as ETRF, at much greater length in another article.

Final Thoughts

Today’s article is another step towards a better understanding of the potential benefits of intermittent fasting on human health.

There are certainly areas of interest that exist in this subject area, but higher quality evidence will be required before more firm claims can be made.

Please do be wary of those who speak about intermittent fasting in a dogmatic fashion, I’m very careful with my clients to be honest about the pros and cons of this approach to food.

For the right person, it is a strategy with great potential – but it’s not for everyone and certainly is never more important for your health than your actual dietary choices.

If you are thinking about incorporating intermittent fasting, know that speaking to a professional like myself is a great choice.

Until next time,

Andy De Santis RD MPH